Research Project

Ongoing projects

Research Project Title	Acronym	Data controller	Lawfulness of processing	Recipients of the data	Data retention period	Category of data	Transfer outside the EU
Matching of the FREGAT clinical and biological database with the SNDS	FREGAT-Link	CHU de Lille	Public interest	Academic	3 years after completion of research	Clinical data	No
Role of socioeconomic and environmental inequalities on esogastric cancers	INEKOG	Lille university, UMR CNRS 9221	Public interest	Academic	Completion of research	Clinical data - Questionnaires	No
Understanding the molecular mechanisms associated with tumor resistance in gastric adenocarcinoma	miniPRESTO	Institut régional du cancer de Montpellier	Public interest	Academic	Completion of research	Clinical data – Tumour samples	No
Biological analyses and response to therapy of esogastric adenocarcinomas with microsatellite instability	ARTEMSI	CHU de Lille	Public interest	Academic	Completion of research	Clinical data – Tumour samples	No
MS Guide surgery for gastric cancer	MS Guide	Lille university / INSERM U1192	Public interest	Academic	Completion of research	Clinical data – Tumour samples	No
Development of a statistical model for the prediction of MSI status from digitized H&E slides of tumor tissue	MSI-IA	CHU de Lille	Public interest	Academic	Completion of research	Clinical data – Tumour samples	No
Using artificial intelligence to predict the molecular subtype and oncologic outcome of patients with adenocarcinoma of the stomach	FREGANET	CHU de Lille	Public interest	Academic	Completion of research	Clinical data – Tumour samples	No
Using artificial intelligence to predict the molecular subtype and oncologic outcome of patients with esophageal adenocarcinoma	FREGATIA	CHU de Lille	Public interest	Academic	Completion of research	Clinical data – Tumour samples	No
The presence of metastatic lymph nodes in esogastric adenocarcinoma: a definitive contraindication to surgery?	OMEGA	Association pour l’étude des maladies digestives	Public interest	Academic	Completion of research	Clinical data	No
Effects of centralization of cancer care on patients' quality of life. Analysis and perspectives from the FREGAT cohort (oesogastric cancers).	CENTRAVIE	Centre Léon Bérard	Public interest	Academic	Completion of research	Clinical data - Questionnaires	No
Disease burden, epidemiology, treatment patterns and healthcare resource utilization in France for locally advanced unresectable or metastatic adenocarcinoma of gastric and gastroesophageal Junction (G/GEJ): an analysis using the FREGAT Database	BECOME	Astellas	Public interest	Industrial	Completion of research	Clinical data	No
Feasibility and efficacy of perioperative treatment in patients over 75 years managed for localized adenocarcinoma of the stomach or GEJ.	STOMAGE	CHU de Lille	Public interest	Academic	Completion of research	Clinical data - Questionnaires	No
Defining Predictive Immunedeterminants of response to neoadjuvant Chemoradiation in Oesophageal adenocarcinoma.	PREDICO	San Raffaele Scientific Institute (Italy)	Public interest	Academic	Completion of research	Clinical data – Biopsies - Blood samples	No
Dissecting metabolic heterogeneity in oesophageal cancer to increase immunotherapy efficacy and overcome resistance	IMPROVE	Institut Pasteur Lille	Public interest	Academic	Completion of research	Clinical data – Biopsies	No
Real world management and outcomes of patients with non-metastatic esophageal squamous cell carcinoma in the FREGAT database	2024-01	CHU de Lille	Public interest	Academic	Completion of research	Clinical data	No
Determination of microbiological factors predictive of response to neoadjuvant therapy in non-metastatic esophageal adenocarcinoma and esogastric junction	MICADOE	CHU de Lille	Public interest	Academic	Completion of research	Clinical data	No
Circulating biomarker signatures for the detection of preneoplastic lesions and gastric cancer.	PREGASIGN	Institut Pasteur	Public interest	Academic	Completion of research	Clinical data - Blood samples	No
EBV + and Gastric Cancer	EBV Estomac	Association des Gastroentérologues Oncologues (AGEO)	Public interest	Academic	Completion of research	Clinical data	No
Evaluation of the administration of artificial nutrition by feeding jejunostomy during neoadjuvant treatment on postoperative morbidity in the context of esophageal or gastric cancer	FREJENO	CHU de Bordeaux	Public interest	Academic	2 years following the last publication of research results	Clinical data	No
Prediction of severe postoperative complications after esogastric surgery using deep learning models, applied to the national FREGAT database	PREDICT-EGS	Laboratoire SYNERGIES	Public interest	Academic	2 years following the last publication of research results	Clinical data	No
Mode of onset of peritoneal carcinomatosis in gastric cancers in Lille over 10 years and selection for surgery	GASTRILILLE	CHU de Lille	Public interest	Academic	2 years following the last publication of research results	Clinical data	No
Postoperative and oncological outcomes of the minimally invasive approach in gastric cancer in France: a retrospective comparative study from the FREGAT database (based on a composite endpoint: TEXTBOOK outcome)	TEXTBOOK outcome	CHU de Lille	Public interest	Academic	2 years following the last publication of research results	Clinical data	No
Validation of a predictive calcium score for the risk of anastomotic leak after oncological esophageal surgery	OESOCALCISCORE	CHU de Limoges	Public interest	Academic	2 years following the last publication of research results	Clinical data	No
Evaluation of the evolution of quality of life during the surgical management of cardia cancers – Trajectory and Impact on Quality of life in Oesogastric cancer over time	TIME-QOG	AP-HP	Public interest	Academic	2 years following the last publication of research results	Clinical data	No
Characterization of the Response Evaluated by transcriptomic Signatures for Chemotherapies and Immunotherapies in esogastric Adenocarcinoma.	CRESCENDO	CHU de Lille	Public interest	Academic	2 years following the last publication of research results	Clinical data	No
SarcopenIa in Gastric cancer iMpact Assessment	SIGMA	CHU de Rennes	Public interest	Academic	2 years following the last publication of research results	Clinical data	No

Completed projects

Research Project Title	Acronym	Data controller	Lawfulness of processing	Recipients of the data	Data retention period	Category of data	Transfer outside the EU
Association between depressive and anxious symptoms and morbidity after surgery in esogastric cancer patients	DAMECHIR / ANDEMOCHIR	Lille university, CNRS UMR 9193	Public interest	Academic	Completion of research	Clinical data - Questionnaires	No
Effect of patients' perceived medical empathy and emotional competence on their adjustment to cancer	CEMA	Lille university, CNRS UMR 9193	Public interest	Academic	Completion of research	Clinical data - Questionnaires	No
Establishment of functional molecular signatures of gastroesophageal junction (GEJ) adenocarcinomas and role in treatment response	EASTMAN	Lille university, CNRS UMR 8161	Public interest	Academic	Completion of research	Clinical data – Tumour samples	No
Impact of patient-physician emotional regulation on the patient's medical outcome	EMOVOL	Lille university, CNRS UMR 9193	Public interest	Academic	Completion of research	Clinical data - Questionnaires	No
Stomach Genome Wide Association Studies (selection of genes predisposing to gastric cancer)	GWAS stomach	CHU de Lille	Public interest	Academic	Completion of research	Clinical data – Blood samples	No
Post esophagectomy mortality root cause analysis	PEMRCA	AP-HP	Public interest	Academic	Completion of research	Clinical data	No
Molecular profiling of esogastric adenocarcinoma recurrences	PROMOREC	CHU de Lille	Public interest	Academic	Completion of research	Clinical data – Tumour samples	No
Identification of therapeutic targets of recurrent gastric independent cell carcinoma by very high-throughput sequencing	REComics	CHU de Lille	Public interest	Academic	Completion of research	Clinical data – Tumour samples	No
Impact of FDG PET after neoadjuvant radiochemotherapy in esophageal cancer patients: value of follow-up?	TEP-oeso-RCT	CHU de Lille	Public interest	Academic	Completion of research	Clinical data	No
Value of histologic response to preoperative chemotherapy in predicting the efficacy of postoperative chemotherapy in gastric adenocarcinoma	TRG	CHU de Lille	Public interest	Academic	Completion of research	Clinical data	No
Assessment and emotional determinants of health-related quality of life deterioration in patients with esogastric cancer	DETAVIE	CHU de Besançon	Public interest	Academic	Completion of research	Clinical data - Questionnaires	No
Assessment of the predictive value of plasma proteins in oesophageal adenocarcinoma treatment	ASPECT	St Andrews University (Scotland)	Public interest	Academic	Completion of research	Clinical data – Blood samples	No
Identification of rare and penetrating germline mutations and genes for gastric cancer, diagnosed before age 50	WES stomach	University Hospital of Marburg, Center for Human genetics (Germany)	Public interest	Academic	Completion of research	Clinical data – Blood samples	No
2019-01	2019-01	Bristol Myers Squibb	Public interest	Industrial	Completion of research	Clinical data	No
2020-01	2020-01	Bristol Myers Squibb	Public interest	Industrial	Completion of research	Clinical data	No
Impact of the COVID-19 pandemic on the stage at diagnosis, treatment and prognosis of patients with esogastric cancer in the FREGAT cohort	CAGOCOVID	CHU de Reims	Public interest	Academic	Completion of research	Clinical data	No
Real-life patient pathway for the management of resectable gastric cancer or cancer of the gastro-oesophageal junction. Retrospective observational study based on secondary data from the FREGAT database.	ARAVIS	Laboratoire AstraZeneca	Public interest	Industrial	Completion of research	Clinical data	No
Assessment of the value of postoperative chemotherapy in gastric adenocarcinoma operated on with a significant pathological response after pre-operative chemotherapy: a French retrospective real-life comparative study from the FREGAT group	STARGATE-1	Nancy university hospital	Public interest	Academic	Completion of research	Clinical data	No
A retrospective cohort study to assess the prevalence of FGFR2b overexpression, biomarkers overlap, patient characteristics and treatment outcomes by FGFR2b status among patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction cancer in the FREGAT database in France (Beluga study).	BELUGA	AMGEN	Public interest	Industrial	Completion of research	Clinical data - Tumours samples	No

Scientific research projects

Ongoing projects

Completed projects